![]() ![]() To our best knowledge, this is the first FO model that deals with the role of the latent reservoir in the persistence of low levels of viremia and of the latent reservoir. The later may be used to better approximations of HIV-infected patients data. ![]() Moreover, the fractional-order derivative distinguishes distinct velocities in the dynamics of the latent reservoir and of plasma virus. The proposed model provides new insights on the role of the latent reservoir in the persistence of the latent reservoir and of the plasma virus. ![]() Our model assumes that (i) the latently infected cells may undergo bystander proliferation, without active viral production, (ii) the latent cell activation rate decreases with time on ART, (iii) the productively infected cells' death rate is a function of the infected cell density. In this paper, we study the role of the latent reservoir in the persistence of the latent reservoir and of the plasma viremia in a fractional-order (FO) model for HIV infection. The factors leading to this persistence are still under debate, but it is now more or less accepted that the latent reservoir may be crucial to the maintenance of this residual viremia. Low levels of viral load are found in HIV-infected patients, after many years under successful suppressive anti-retroviral therapy (ART). Persistence of low levels of plasma viremia and of the latent reservoir in patients under ART: A fractional-order approach ![]()
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